（2R，3S，5R）-5-（4-氨基-7H-吡咯[2,3-D]嘧啶-7-基-2 -（羟甲基）四氢呋喃-3-醇合成路线 （共 28 条）
反应条件
1: 66 percent / Raney nickel / H2O; ethanol / 2.5 h / Heating 2: 90 percent / H2, K2CO3 / 10percent Pd/C / H2O; propan-1-ol / 8 h / 1520 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1461 - 1467
反应条件
1: 79 percent / NH3 / methanol / 16 h / 120 °C 2: 90 percent / H2, K2CO3 / 10percent Pd/C / H2O; propan-1-ol / 8 h / 1520 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1461 - 1467
反应条件
1: 1) N-benzyl triethyl ammonium chloride, 50 percent NaOH; 2) CH3ONa / 1) benzene, DME, 45 min.; 2) CH3OH, 24 h at room temp. 2: 67 percent / Raney nickel / N,N-dimethyl-acetamide / 2 h / Heating View Scheme
参考文献
, vol. No. 5, p. 876 - 884
反应条件
1: 79 percent / CH3ONa / methanol / 24 h / Ambient temperature 2: 67 percent / Raney nickel / N,N-dimethyl-acetamide / 2 h / Heating View Scheme
参考文献
, vol. No. 5, p. 876 - 884
反应条件
ammonium hydroxide in water T=60°C; Rate constant;
参考文献
Helvetica Chimica Acta, , vol. 78, # 1 p. 94 - 108
反应条件
hydrogenchloride in water T=70°C; 3 h;
参考文献
Seela, Frank; Menkhoff, Sabine; Behrendt, Silvia
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1986 , p. 525 - 530
反应条件
1: 92 percent / 2.) trimethylchlorsilan / Ambient temperature; 1.) pyridine, 2 h, 2.) 2 h
2: 76 percent / N-ethyldiisopropylamine / pyridine / 3 h / Ambient temperature
View Scheme
参考文献
Seela; Kehne
Tetrahedron, 1985 , vol. 41, # 22 p. 5387 - 5392
反应条件
chloro-trimethyl-silane
Ambient temperature1.) pyridine, 2 h, 2.) 2 h;
参考文献
Seela; Kehne
Tetrahedron, 1985 , vol. 41, # 22 p. 5387 - 5392
