7-(N-叔丁氧羰基氨基)庚酸合成路线 （共 7 条）
反应条件
sodium hydroxide in 1,4-dioxane; water T=0 - 20°C;
参考文献
Gavande, Navnath; Kim, Hye-Lim; Doddareddy, Munikumar R.; Johnston, Graham A. R.; Chebib, Mary; Hanrahan, Jane R.
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 4 p. 402 - 407
反应条件
lithium hydroxide hydrate in tetrahydrofuran; water T=20°C; 0.5 h; Inert atmosphere;
参考文献
Shirokane, Kenji; Wada, Takamasa; Yoritate, Makoto; Minamikawa, Ryo; Takayama, Nobuaki; Sato, Takaaki; Chida, Noritaka
Angewandte Chemie - International Edition, 2014 , vol. 53, # 2 p. 512 - 516
Angew. Chem., 2014 , vol. 126, # 2 p. 522 - 526,5
反应条件
N,N,N1,N1-tetramethylguanidine in dimethyl sulfoxide
反应条件
sodium hydrogencarbonate Yield given;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 14 p. 1937 - 1940
反应条件
1: BH3 / tetrahydrofuran / 1 h 2: Ph3P, CBr4 / tetrahydrofuran; acetonitrile / 24 h View Scheme
参考文献
Egbertson, Melissa S.; Chang, Charles T.-C.; Duggan, Mark E.; Gould, Robert J.; Halczenko, Wasyl; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2537 - 2551
反应条件
1: 1.) N-methylmorpholine, ethyl chloroformate, 2.) LiBH4 / 1.) THF, 0 deg C, 1 h, 2.) THF, from 0 deg C to RT, 3 h 2: TFA / CH2Cl2 / 1 h View Scheme
参考文献
Boden, Phil; Eden, Jon M.; Hodgson, Julie; Horwell, David C.; Hughes, John; McKnight, Alexander T.; Lewthwaite, Russell A.; Pritchard, Martyn C.; Raphy, Jenny; Meecham, Ken; Ratcliffe, Giles S.; Suman-Chauhan, Nirmala; Woodruff, Geoffrey N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 8 p. 1664 - 1675
反应条件
1: With diazomethyl-trimethyl-silane in hexanes; benzene T=20°C; 0.5 h; 2: With hydrogenchloride in 1,4-dioxane T=20°C; 2 h;
参考文献
SUNESIS PHARMACEUTICALS, INC.; MORROW, Joelle
Patent: WO2005/34840 A2, 2005 ;
Location in patent: Page/Page column 70-71 ;
WO 2005/034840 A2
