1,1-环己基二乙酸单甲酯合成路线 （共 3 条）
反应条件
1: 1,1-Cyclohexanediacetic acid With acetic anhydride
5 h; Heating / reflux;
2: methanol With boron trifluoride diethyl etherate
T=20°C; 2 h;
参考文献
Kyorin Pharmaceutical Co., Ltd.; Nisshin Pharma Inc.
Patent: EP1443046 A1, 2004 ;
Location in patent: Page 45 ;
EP 1443046 A1
反应条件
1: acetyl chloride / 3 h / 60 °C
2: 6.27 g / methanol / 12 h / Heating
View Scheme
参考文献
Stymiest, Jake L.; Mitchell, Bryan F.; Wong, Susan; Vederas, John C.
Journal of Organic Chemistry, 2005 , vol. 70, # 20 p. 7799 - 7809
反应条件
in methanol
12 h; Heating;
参考文献
Stymiest, Jake L.; Mitchell, Bryan F.; Wong, Susan; Vederas, John C.
Journal of Organic Chemistry, 2005 , vol. 70, # 20 p. 7799 - 7809
