3-(哌啶-4-基)-1H-吲哚盐酸盐合成路线 （共 5 条）
反应条件
hydrogenchloride in 1,4-dioxane
T=20°C; 2 h;
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN Randamp;;D; reMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; MARCHAND, Arnaud; ALLASIA, Sara; KILONDA, Amuri; CHALTIN, Patrick
Patent: WO2010/142801 A1, 2010 ;
Location in patent: Page/Page column 201 ;
WO 2010/142801 A1
反应条件
hydrogenchloride; palladium 10 on activated carbon; hydrogen in methanol; water
3 h;
参考文献
Conway, Richard J.; Valant, Celine; Christopoulos, Arthur; Robertson, Alan D.; Capuano, Ben; Crosby, Ian T.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2560 - 2564
反应条件
1.1: dichloromethane / 1 h / 20 °C
1.2: 24 h / 20 °C
2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C
2.2: 0.5 h / 0 - 20 °C
View Scheme
参考文献
Yang, Shyh-Ming; Tang, Yuting; Zhang, Rui; Lu, Huajun; Kuo, Gee-Hong; Gaul, Michael D.; Li, Yaxin; Ho, George; Conway, James G.; Liang, Yin; Lenhard, James M.; Demarest, Keith T.; Murray, William V.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6773 - 6776
反应条件
1.1: dichloromethane / 1 h / 20 °C
1.2: 24 h / 20 °C
2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C
2.2: 0.5 h / 0 - 20 °C
View Scheme
参考文献
Yang, Shyh-Ming; Tang, Yuting; Zhang, Rui; Lu, Huajun; Kuo, Gee-Hong; Gaul, Michael D.; Li, Yaxin; Ho, George; Conway, James G.; Liang, Yin; Lenhard, James M.; Demarest, Keith T.; Murray, William V.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6773 - 6776
反应条件
1: potassium hydroxide / methanol / 5.5 h / Reflux
2: hydrogenchloride; palladium 10 on activated carbon; hydrogen / methanol; water / 3 h
View Scheme
参考文献
Conway, Richard J.; Valant, Celine; Christopoulos, Arthur; Robertson, Alan D.; Capuano, Ben; Crosby, Ian T.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2560 - 2564
