1: 1-bromo-2-chloro-benzene With magnesium; ethylene dibromide in tetrahydrofuran 1.58333 h; 2: (4-chlorophenyl)(pyrimidin-5-yl)methanone With zinc(II) chloride in tetrahydrofuran T=20°C; 0.5 h;

n-butyllithium in tetrahydrofuran; hexane T=-95 - 20°C;

1.1: potassium permanganate / ethyl acetate; water / 6 h / Reflux 2.1: magnesium / ethylene dibromide / tetrahydrofuran / 1.58 h 2.2: 0.5 h / 20 °C View Scheme

1.1: lithium chloride / NiCl2((PPh3)P)2 / tetrahydrofuran / 5 h / 0 °C 2.1: potassium permanganate / ethyl acetate; water / 6 h / Reflux 3.1: magnesium / ethylene dibromide / tetrahydrofuran / 1.58 h 3.2: 0.5 h / 20 °C View Scheme