1-苄基-吡咯烷-2-羧酸合成路线 （共 7 条）
反应条件
hydrogenchloride; sulfuric acid 2.) reflux, 16 h; Multistep reaction;
参考文献
Rispens, Minze T.; Gelling, Onko Jan; De Vries, Andre H.M.; Meetsma, Auke; Van Bolhuis, Fre; Feringa, Ben L.
Tetrahedron, 1996 , vol. 52, # 10 p. 3521 - 3546
反应条件
copper(l) iodide; di-tert-butyl peroxide in toluene T=110°C; Inert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 48, # 4 p. 792 - 795
反应条件
potassium hydroxide in chloroform; isopropyl alcohol
参考文献
Centre National de la Recherche Scientifique (CNRS); Universite Louis Pasteur
Patent: US7745413 B2, 2010 ;
反应条件
1: With potassium hydroxide in isopropyl alcohol
T=40°C;
2: With hydrogenchloride in water; isopropyl alcohol
pH=4 - 5;
参考文献
Tang, Yi-Qiang; Lu, Jian-Mei; Wang, Xiu-Ren; Shao, Li-Xiong
Tetrahedron, 2010 , vol. 66, # 40 p. 7970 - 7974
反应条件
sodium carbonate in ethanol
3 h; Heating;
参考文献
Lochead, Alistair W.; Proctor, George R.; Caton, Michael P. L.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 11 p. 2477 - 2489
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=0°C; 3 h; Inert atmosphereReflux;
2: With water; potassium hydroxide in tetrahydrofuran
T=20°C;
参考文献
Tang, Yi-Qiang; Lu, Jian-Mei; Wang, Xiu-Ren; Shao, Li-Xiong
Tetrahedron, 2010 , vol. 66, # 40 p. 7970 - 7974
反应条件
1: 1.) aq. HCl, 2.) conc. H2SO4 / 2.) reflux, 16 h
2: NH3(gas) / methanol / 40 h / 80 °C
3: 1.) LiAlH4, 2.) aq. KOH / tetrahydrofuran / 16 h
View Scheme
参考文献
Rispens, Minze T.; Gelling, Onko Jan; De Vries, Andre H.M.; Meetsma, Auke; Van Bolhuis, Fre; Feringa, Ben L.
Tetrahedron, 1996 , vol. 52, # 10 p. 3521 - 3546
