(1R,4S)-顺-4-乙酰氧基-2-环戊烯-1-醇合成路线 （共 32 条）
反应条件
1: With tris-(dibenzylideneacetone)dipalladium(0); triphenylphosphine on polystyrene in tetrahydrofuran T=20°C; 0.25 h; 2: With triethylamine in tetrahydrofuran T=50°C; 1 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/147659 A1, 2007 ;
Location in patent: Page/Page column 30 ;
WO 2007/147659 A1
反应条件
1.1: CuI / tetrahydrofuran
2.1: DIAD; PPh3 / tetrahydrofuran / -78 °C
3.1: tetrahydrofuran / 2 h
4.1: H2O2; KF; KHCO3 / 60 - 65 °C
5.1: Imidazole
6.1: O3 / propan-1-ol / -70 °C
6.2: Me2S / propan-1-ol
7.1: NaBH4 / propan-1-ol / 0 °C
8.1: I2; Imidazole; PPh3
9.1: dioxane / 2 h / 115 °C
10.1: 76 percent / Bu4NF
View Scheme
参考文献
Igarashi, Junji; Ishiwata, Hiroyuki; Kobayashi, Yuichi
Tetrahedron Letters, 2004 , vol. 45, # 43 p. 8065 - 8068
