2,3,4,5,6-五氟苯甲酸合成路线 （共 133 条）
反应条件
sodium hydroxide; water; zinc T=60°C; Substitution; Hydrodefluorination; 20 h; Title compound not separated from byproducts;
参考文献
Journal of Physical Chemistry A, , vol. 104, # 2 p. 352 - 361
反应条件
1: PCl5 2: NH3 View Scheme
参考文献
Barbour,A.K. et al.
Journal of the Chemical Society, 1961 , p. 808 - 817
反应条件
zinc in ammonium hydroxide 5 h; Ambient temperature;
参考文献
Laev, Sergey S.; Shteingarts, Vitalii D.
Journal of Fluorine Chemistry, 1999 , vol. 96, # 2 p. 175 - 185
反应条件
4-(N,N-dimethlyamino)pyridine; C21H27AuN2 in dichloromethane T=40°C; 12 h; Inert atmosphere;
参考文献
Lv, Hongbin; Zhan, Jin-Hui; Cai, Yuan-Bo; Yu, Yi; Wang, Bingwu; Zhang, Jun-Long
Journal of the American Chemical Society, 2012 , vol. 134, # 39 p. 16216 - 16227,12
反应条件
t-Bu-XantPhos; tBuXantphosAu(AuCl2); (Ph)2SiH2; acetic acid in 1,2-dichloro-ethane T=80°C; 24 h; Inert atmosphere;
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 8 p. 1529 - 1541
反应条件
sodium hydroxide; water; zinc T=60°C; Substitution; Hydrodefluorination; 20 h; Title compound not separated from byproducts;
参考文献
Journal of Physical Chemistry A, , vol. 104, # 2 p. 352 - 361
反应条件
ammonia; sodium T=-45°C; 0.25 h; defluorination by various reduction conditions; Product distribution;
参考文献
Tetrahedron Letters, , vol. 36, # 26 p. 4655 - 4658
反应条件
[Fe(II)(TPA)(CH3CN)2](OTf)2; water; dihydrogen peroxide in acetonitrile T=20°C;
参考文献
Das, Parthapratim; Que Jr., Lawrence
Inorganic Chemistry, 2010 , vol. 49, # 20 p. 9479 - 9485
反应条件
1: 96 percent / conc. H2SO4 / CCl4 / Heating 2: 87 percent / NaN3 / acetone; H2O / 8 h / Heating 3: 98 percent / 20percent aq. NaOH / methanol; H2O / 25 °C View Scheme
参考文献
Keana, John F. W.; Cai, Sui Xiong
Journal of Organic Chemistry, 1990 , vol. 55, # 11 p. 3640 - 3647
反应条件
1,10-phenanthroline; nickel dichloride; zinc in water; N,N-dimethyl-formamide T=50°C; Hydrodefluorination; 6 h; Product distribution; Further Variations:ReagentsTemperaturesreaction time;
参考文献
Journal of Fluorine Chemistry, , vol. 101, # 1 p. 65 - 67
