2,3,4,5,6-五氟苯甲酸合成路线 （共 133 条）
反应条件
[Cu(Phen)(PPh3)2]NO3; potassium tert-butylate; palladium diacetate in 1-methyl-pyrrolidin-2-one
T=170°C; 1 h; SonicationContinuous flow reactor;
参考文献
Lange, Paul P.; Goossen, Lukas J.; Podmore, Philip; Underwood, Toby; Sciammetta, Nunzio
Chemical Communications, 2011 , vol. 47, # 12 p. 3628 - 3630
反应条件
1: 96 percent / conc. H2SO4 / CCl4 / Heating
2: 87 percent / NaN3 / acetone; H2O / 8 h / Heating
3: 66 percent / acetophenone / cyclohexane / 5 h / Irradiation
View Scheme
参考文献
Senaweera, Sameera M.; Singh, Anuradha; Weaver, Jimmie D.
Journal of the American Chemical Society, 2014 , vol. 136, # 8 p. 3002 - 3005
反应条件
4-(dimethylamino)pyridinium tosylate; diisopropyl-carbodiimide in dichloromethane
T=0 - 20°C; 20 h;
参考文献
Kishikawa, Keiki; Haga, Yuri; Inoue, Takahiro; Watanabe, Tomohiro; Takahashi, Masahiro; Kohmoto, Shigeo
Chemistry Letters, 2012 , vol. 41, # 11 p. 1465 - 1467
反应条件
1: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=20°C; 4 h;
2: With triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone in dichloromethane
T=0 - 20°C; Inert atmosphere;
参考文献
Yu, Daohong; Lu, Long; Shen, Qilong
Organic Letters, 2013 , vol. 15, # 4 p. 940 - 943
反应条件
1: PCl5
2: diethyl ether
View Scheme
参考文献
Barbour,A.K. et al.
Journal of the Chemical Society, 1961 , p. 808 - 817
反应条件
1: aq. NaOH, NaHS / 2 h / 70 °C
2: 978 mg / 30percent H2O2, AcOH / 2 h / 70 °C
3: SOCl2, DMF / 6 h / Heating
4: NaF, Ph4PBr / various solvent(s) / 10 h / 155 °C
5: diethyl ether
View Scheme
参考文献
Fielding, H. C.; Shirley, I. M.
Journal of Fluorine Chemistry, 1992 , vol. 59, # 1 p. 15 - 31
反应条件
4-(N,N-dimethlyamino)pyridine in tert-butyl alcohol
T=40°C; 18 h;
参考文献
Senaweera, Sameera M.; Singh, Anuradha; Weaver, Jimmie D.
Journal of the American Chemical Society, 2014 , vol. 136, # 8 p. 3002 - 3005
反应条件
1: sulfuric acid / |Reflux
2: [iridium(III)(2-phenylpyridine)3]; N-ethyl-N,N-diisopropylamine / acetonitrile; benzene-d6 / 45 h / 0 °C / |Inert atmosphere; |Irradiation
View Scheme
参考文献
Senaweera, Sameera M.; Singh, Anuradha; Weaver, Jimmie D.
Journal of the American Chemical Society, 2014 , vol. 136, # 8 p. 3002 - 3005
反应条件
sodium carbonate in water
Heating;
参考文献
Onaka, Satoru; Sakai, Yoichi; Ozeki, Tomoji; Nakamoto, Tadahiro; Kobayashi, Yusuke; Takahashi, Masashi; Ogiso, Ryo; Takayama, Tsutomu; Shiotsuka, Michito
Dalton Transactions, 2014 , vol. 43, # 18 p. 6711 - 6719
反应条件
in ethanol; toluene
equimolar amts., refluxing for 4-6 h (distn. off of azeotropes); evapn., recrystn. (CCl4);
参考文献
Willem, Rudolph; Bouhdid, Abdeslam; Biesemans, Monique; Martins, Jose C.; De Vos, Dick; Tiekink, Edward R.T.; Gielen, Marcel
Journal of Organometallic Chemistry, 1996 , vol. 514, # 1-2 p. 203 - 212
