7-氯-2-碘噻吩并[3,2-b]吡啶合成路线 （共 5 条）
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-70°C; 2 h; Inert atmosphereLarge scale; 2: With iodine in tetrahydrofuran; hexane T=-70 - 20°C; 19.3 h; Inert atmosphereLarge scale;
参考文献
Ragan; Raggon; Hill; Jones; McDermott; Munchhof; Marx; Casavant; Cooper; Doty; Lu
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 676 - 683
反应条件
1: 72 percent / oxalyl chloride / 1,2-dichloro-ethane; dimethylformamide 2: BuLi; I2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 1 p. 21 - 24
反应条件
1.1: diphenylether / 245 °C 2.1: oxalyl dichloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane 3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -70 °C / |Inert atmosphere; |Large scale 3.2: 19.3 h / -70 - 20 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 5 p. 676 - 683
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; acetonitrile T=50°C; 5 h; Inert atmosphereLarge scale;
参考文献
Scott, Robert W.; Neville, Scan N.; Urbina, Armando; Camp, David; Stankovic, Nebojsa
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 296 - 303
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=95°C; Stille Cross Coupling; 40 h; Inert atmosphereLarge scale;
参考文献
Ragan; Raggon; Hill; Jones; McDermott; Munchhof; Marx; Casavant; Cooper; Doty; Lu
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 676 - 683
