1: 4'-hydroxy-2,2',4-tribromodiphenyl ether With bromine in acetic acid T=20°C; 3 h; 2: methyl iodide With sodium hydroxide; tetra(n-butyl)ammonium hydroxide in dichloromethane; water T=20°C; 5 h; Further stages.;

1.1: 78 percent / Na2CO3 / N,N-dimethyl-acetamide / 2 h / Heating 2.1: KH2PO4; CF3CO3H / CH2Cl2 / 1.5 h / 0 °C 2.2: 95 percent / hydrochloric acid / methanol / 15 h 3.1: bromine / acetic acid / 3 h / 20 °C 3.2: 64 percent / NaOH; tetrabutylammonium hydroxide / CH2Cl2; H2O / 5 h / 20 °C View Scheme

1.1: 78 percent / Na2CO3 / N,N-dimethyl-acetamide / 2 h / Heating 2.1: KH2PO4; CF3CO3H / CH2Cl2 / 1.5 h / 0 °C 2.2: 95 percent / hydrochloric acid / methanol / 15 h 3.1: bromine / acetic acid / 3 h / 20 °C 3.2: 64 percent / NaOH; tetrabutylammonium hydroxide / CH2Cl2; H2O / 5 h / 20 °C View Scheme

1.1: KH2PO4; CF3CO3H / CH2Cl2 / 1.5 h / 0 °C 1.2: 95 percent / hydrochloric acid / methanol / 15 h 2.1: bromine / acetic acid / 3 h / 20 °C 2.2: 64 percent / NaOH; tetrabutylammonium hydroxide / CH2Cl2; H2O / 5 h / 20 °C View Scheme