1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸合成路线 (共 13 条)
反应条件
sodium hydroxide in water T=0 - 75°C; pH=10 - 10.5;
参考文献
WO2013/76743 A2, ;
Page/Page column 4; 5 ;
反应条件
sodium hydroxide in water T=70°C; pH=9.5 - 10; 30 h;
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 46, # 3 p. 197 - 209
反应条件
tri-iso-propylsilane; water; trifluoroacetic acid 3 h; TimeReagent/catalystSolvent;
参考文献
Tetrahedron Letters, , vol. 53, # 50 p. 6810 - 6814
反应条件
tri-iso-propylsilane; water; trifluoroacetic acid 0.833333 h; TimeReagent/catalystSolvent;
参考文献
Tetrahedron Letters, , vol. 53, # 50 p. 6810 - 6814
反应条件
1: 78 percent / K2CO3 / dimethylformamide / 30 h / 100 °C 2: 33 percent / conc. H2SO4 / 28 h / 115 °C 3: 88 percent / NaOH / H2O / 30 h / 70 °C / pH 9.5 - 10 View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 46, # 3 p. 197 - 209
反应条件
1: 33 percent / conc. H2SO4 / 28 h / 115 °C 2: 88 percent / NaOH / H2O / 30 h / 70 °C / pH 9.5 - 10 View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 46, # 3 p. 197 - 209
反应条件
1: 97 percent / Et3N / acetonitrile / 5 h / 20 °C 2: 78 percent / K2CO3 / dimethylformamide / 30 h / 100 °C 3: 33 percent / conc. H2SO4 / 28 h / 115 °C 4: 88 percent / NaOH / H2O / 30 h / 70 °C / pH 9.5 - 10 View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 46, # 3 p. 197 - 209
反应条件
1: potassium carbonate / acetonitrile / 16 h / 20 °C 2: tetrakis(triphenylphosphine) palladium(0); 4-methyl-morpholine / dichloromethane / 2 h / 20 °C 3: tri-iso-propylsilane; trifluoroacetic acid; water / 3 h View Scheme
参考文献
Tetrahedron Letters, , vol. 53, # 50 p. 6810 - 6814
反应条件
1: tetrakis(triphenylphosphine) palladium(0); 4-methyl-morpholine / dichloromethane / 3 h / 20 °C 2: tri-iso-propylsilane; trifluoroacetic acid; water / 0.83 h View Scheme
参考文献
Tetrahedron Letters, , vol. 53, # 50 p. 6810 - 6814
反应条件
1: tetrakis(triphenylphosphine) palladium(0); 4-methyl-morpholine / dichloromethane / 2 h / 20 °C 2: tri-iso-propylsilane; trifluoroacetic acid; water / 3 h View Scheme
参考文献
Tetrahedron Letters, , vol. 53, # 50 p. 6810 - 6814