water

lithium hydroxide in tetrahydrofuran 6 h; Heating;

1: 1,2,4-trimethoxy benzene With n-butyllithium in diethyl ether; hexane T=-10 - 20°C; Inert atmosphere; 2: methyl chloroformate in diethyl ether; hexane T=-10°C; Inert atmosphere;

1.1: n-butyllithium / diethyl ether; hexane / 3.5 h / 0 - 20 °C 1.2: 75 percent / diethyl ether; hexane / -60 - 20 °C 2.1: 94 percent / lithium hydroxide monohydrate / tetrahydrofuran / 6 h / Heating View Scheme

hydrogenchloride