吡咯并[1,2-a]喹喔啉-4(5H)-酮合成路线 （共 22 条）
参考文献
Adir Et Compagnie
Patent: US5599812 A1, 1997 ;
反应条件
1: With copper(l) iodide; potassium carbonate; L-proline in dimethyl sulfoxide
T=80°C; 25 h;
2: With water in dimethyl sulfoxide
T=60°C; 8 h; Further stages.;
参考文献
Yuan, Qiliang; Ma, Dawei
Journal of Organic Chemistry, 2008 , vol. 73, # 13 p. 5159 - 5162
反应条件
potassium hydroxide in ethylene glycol
T=145°C; 4 h;
参考文献
Campiani; Nacci; Corelli; Anzini
Synthetic Communications, 1991 , vol. 21, # 15-16 p. 1567 - 1576
反应条件
triethylamine in water; acetone; acetonitrile
参考文献
Adir Et Compagnie
Patent: US5599812 A1, 1997 ;
反应条件
dichloro bis(acetonitrile) palladium(II); cupric trifluoroacetate; trifluoroacetic acid in 1,4-dioxane
T=90°C;
参考文献
Liang, Dongdong; Hu, Ziwei; Peng, Jiangling; Huang, Jinbo; Zhu, Qiang
Chemical Communications, 2013 , vol. 49, # 2 p. 173 - 175
反应条件
copper(l) iodide; potassium carbonate; L-proline in dimethyl sulfoxide
T=80°C; 25 h;
参考文献
Yuan, Qiliang; Ma, Dawei
Journal of Organic Chemistry, 2008 , vol. 73, # 13 p. 5159 - 5162
反应条件
1: BiCl3; NaBH4 / ethanol
2: toluene / Heating
View Scheme
参考文献
Guillon, Jean; Grellier, Philippe; Labaied, Mehdi; Sonnet, Pascal; Leger, Jean-Michel; Deprez-Poulain, Rebecca; Forfar-Bares, Isabelle; Dallemagne, Patrick; Lemaitre, Nicolas; Pehourcq, Fabienne; Rochette, Jacques; Sergheraert, Christian; Jarry, Christian
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1997 - 2009
反应条件
1: AcOH / Heating
2: BiCl3; NaBH4 / ethanol
3: toluene / Heating
View Scheme
参考文献
Guillon, Jean; Grellier, Philippe; Labaied, Mehdi; Sonnet, Pascal; Leger, Jean-Michel; Deprez-Poulain, Rebecca; Forfar-Bares, Isabelle; Dallemagne, Patrick; Lemaitre, Nicolas; Pehourcq, Fabienne; Rochette, Jacques; Sergheraert, Christian; Jarry, Christian
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1997 - 2009
反应条件
in dichloromethane
2 h; Ambient temperature;
参考文献
Molina, Pedro; Alajarin, Mateo; Vidal, Angel
Tetrahedron, 1990 , vol. 46, # 3 p. 1063 - 1078
反应条件
1: dichloromethane / 20 °C / Cooling with ice; Inert atmosphere
2: copper(l) iodide; sodium hydride; L-proline / N,N-dimethyl-formamide / 0.08 h / 140 - 160 °C / Inert atmosphere; Microwave irradiation
View Scheme
参考文献
Vaillard, Victoria A.; Rossi, Roberto A.; Martin, Sandra E.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 13 p. 4927 - 4935
