吡咯并[1,2-a]喹喔啉-4(5H)-酮合成路线 （共 22 条）
反应条件
1: oxalyl dichloride / 1 h / 50 °C / Inert atmosphere
2: dichloromethane / 20 °C / Cooling with ice; Inert atmosphere
3: copper(l) iodide; sodium hydride; L-proline / N,N-dimethyl-formamide / 0.08 h / 140 - 160 °C / Inert atmosphere; Microwave irradiation
View Scheme
参考文献
Vaillard, Victoria A.; Rossi, Roberto A.; Martin, Sandra E.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 13 p. 4927 - 4935
参考文献
Guillon, Jean; Grellier, Philippe; Labaied, Mehdi; Sonnet, Pascal; Leger, Jean-Michel; Deprez-Poulain, Rebecca; Forfar-Bares, Isabelle; Dallemagne, Patrick; Lemaitre, Nicolas; Pehourcq, Fabienne; Rochette, Jacques; Sergheraert, Christian; Jarry, Christian
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1997 - 2009
反应条件
1: dichloromethane / 20 °C / Cooling with ice; Inert atmosphere
2: copper(l) iodide; sodium hydride; L-proline / N,N-dimethyl-formamide / 1 h / Reflux; Inert atmosphere
View Scheme
参考文献
Vaillard, Victoria A.; Rossi, Roberto A.; Martin, Sandra E.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 13 p. 4927 - 4935
反应条件
1: copper(l) iodide; sodium hydride; L-proline / N,N-dimethyl-formamide / 0.42 h / 140 - 160 °C / Inert atmosphere; Microwave irradiation
2: copper(l) iodide; sodium hydride; L-proline / N,N-dimethyl-formamide / 0.08 h / 140 - 160 °C / Inert atmosphere; Microwave irradiation
View Scheme
参考文献
Vaillard, Victoria A.; Rossi, Roberto A.; Martin, Sandra E.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 13 p. 4927 - 4935
反应条件
1: oxalyl dichloride / 1 h / 50 °C / Inert atmosphere
2: dichloromethane / 20 °C / Cooling with ice; Inert atmosphere
3: copper(l) iodide; sodium hydride; L-proline / N,N-dimethyl-formamide / 1 h / Reflux; Inert atmosphere
View Scheme
参考文献
Vaillard, Victoria A.; Rossi, Roberto A.; Martin, Sandra E.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 13 p. 4927 - 4935
反应条件
1: copper(l) iodide; sodium hydride; L-proline / N,N-dimethyl-formamide / 0.42 h / 140 - 160 °C / Inert atmosphere; Microwave irradiation
2: copper(l) iodide; sodium hydride; L-proline / N,N-dimethyl-formamide / 1 h / Reflux; Inert atmosphere
View Scheme
参考文献
Vaillard, Victoria A.; Rossi, Roberto A.; Martin, Sandra E.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 13 p. 4927 - 4935
反应条件
1: glacial acetic acid / 1 h / 115 °C
3: 93 percent / KOH / ethane-1,2-diol / 4 h / 145 °C
View Scheme
参考文献
Campiani; Nacci; Corelli; Anzini
Synthetic Communications, 1991 , vol. 21, # 15-16 p. 1567 - 1576
反应条件
2: 93 percent / KOH / ethane-1,2-diol / 4 h / 145 °C
View Scheme
参考文献
Campiani; Nacci; Corelli; Anzini
Synthetic Communications, 1991 , vol. 21, # 15-16 p. 1567 - 1576
反应条件
2: Ambient temperature
View Scheme
参考文献
Molina, Pedro; Alajarin, Mateo; Vidal, Angel
Tetrahedron Letters, 1989 , vol. 30, # 21 p. 2847 - 2850
反应条件
1: Ambient temperature
View Scheme
参考文献
Molina, Pedro; Alajarin, Mateo; Vidal, Angel
Tetrahedron Letters, 1989 , vol. 30, # 21 p. 2847 - 2850
