in water T=37°C; 6 h; enzymes: leucine aminopeptidase, carboxypeptidase B; degradation in extracts of various mucosae (nasal, rectal, vaginal); female New Zealand White Albino rabbits; different inhibitors (amastatin, thimerosal, thiorphan); Product distribution;

1H-imidazole; polymer-bound 4-hydroxy-3-nitrobenzophenone,DCC; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide 1.) CH2Cl2, THF, 1 H, 25 deg C, -10 -0 deg C,10 h; 2.) 0 deg C, CH2Cl2, 24 h; Yield given. Multistep reaction;

aminopeptidase M (EC3.4.11.2); tri-(hydroxymethyl)-methylamine T=37°C; Hydrolysis; pH=7.02; 1 h; Kinetics;

in water T=37°C; 6 h; enzymes: leucine aminopeptidase , carboxypeptidase B; degradation in extracts of various mucosae (nasal, rectal, vaginal); female White Albino rabbits; different inhibitors (amastatin, thimerosal, thiorphan); pH=5-8; Product distributionRate constant;