反应条件
1.1: acetic anhydride / isopropanol acetate / 60 °C / |Inert atmosphere; |Large scale 2.1: ammonium hydroxide / 2.5 h / 0 - 15 °C / |Inert atmosphere; |Large scale 2.2: 20 °C / |Inert atmosphere; |Large scale 3.1: potassium hydroxide; bromine / water / 1.5 h / 0 - 75 °C / |Inert atmosphere; |Large scale 4.1: thionyl chloride / ethylene glycol dimethyl ether / 12 h / 50 °C / |Large scale 5.1: ammonium hydroxide / 40 °C / |Large scale 6.1: hydrogen / water; ethanol; ethyl acetate / 1.67 h / 40 °C / 2828.7 Torr / |Cooling; |Large scale View Scheme
参考文献
Barkalow, Jufang H.; Breting, Jeffrey; Gaede, Bruce J.; Haight, Anthony R.; Henry, Rodger; Kotecki, Brian; Mei, Jianzhang; Pearl, Kurt B.; Tedrow, Jason S.; Viswanath, Shekhar K.
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 693 - 698
