反应条件
1: 63 percent / n-BuLi / tetrahydrofuran / 1 h
2: POCl3 / pyridine / 1.) room temp, 1 h, 2:) 75 deg C, 1.5 h
3: NaBH4 / ethanol / 2 h
4: 55 percent / tetrahydrothiophene 1,1-dioxide / 0.5 h / 120 °C
5: 2.) Et3N / 1.) CH3Cl, r.t.; 2.) EtOAc, r.t.
6: 90 percent / N-benzyl acridinium bromide / acetonitrile / 1 h / Ambient temperature
7: 80 percent / H2, NaHCO3 / 10percent Pd-C / ethanol / 5 h / 760 Torr
8: 25 percent / 50percent aq KOH / tetrahydrofuran; ethane-1,2-diol / 1.) THF, 20 deg C, 3 h and reflux, 5 min, 2.) ethylene glycol, 160 deg C, 15 min
View Scheme
参考文献
Wanner; Koomen; Pandit
Tetrahedron, 1983 , vol. 39, # 22 p. 3673 - 3681
