3-(4'-溴[1,1'-联苯]-4-基)-3,4-二氢萘并醛烯-1(2H)-酮合成路线 （共 15 条）
反应条件
sodium tetrahydroborate in ethanol T=20°C; 2 h;
参考文献
Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531
反应条件
aluminium trichloride in toluene
T=90°C; 16 h;
参考文献
Van Heerden, Pieter S.; Bezuidenhoudt, Barend C. B.; Ferreira, Daneel
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 8 p. 1141 - 1146
参考文献
Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531
反应条件
1: 95 percent / Zn; I2 / benzene / 1 h / Heating
2: 85 percent / Et3SiH; TFA; BF3*Et2O / CH2Cl2 / 8 h / Heating
3: 93 percent / aq. KOH / 8 h / Heating
4: 80 percent / polyphosphoric acid / 1 h / 80 °C
View Scheme
参考文献
Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531
反应条件
1: 88 percent / AlCl3 / CH2Cl2 / 16 h / -10 °C
2: 95 percent / Zn; I2 / benzene / 1 h / Heating
3: 85 percent / Et3SiH; TFA; BF3*Et2O / CH2Cl2 / 8 h / Heating
4: 93 percent / aq. KOH / 8 h / Heating
5: 80 percent / polyphosphoric acid / 1 h / 80 °C
View Scheme
参考文献
Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531
反应条件
1: 88 percent / AlCl3 / CH2Cl2 / 16 h / -10 °C
2: 95 percent / Zn; I2 / benzene / 1 h / Heating
3: 85 percent / Et3SiH; TFA; BF3*Et2O / CH2Cl2 / 8 h / Heating
4: 93 percent / aq. KOH / 8 h / Heating
5: 80 percent / polyphosphoric acid / 1 h / 80 °C
View Scheme
参考文献
Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531
反应条件
1: 85 percent / Et3SiH; TFA; BF3*Et2O / CH2Cl2 / 8 h / Heating
2: 93 percent / aq. KOH / 8 h / Heating
3: 80 percent / polyphosphoric acid / 1 h / 80 °C
View Scheme
参考文献
Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531
参考文献
Shadbolt; Woodward; Birchwood
Journal of the Chemical Society. Perkin transactions 1, 1976 , # 11 p. 1190 - 1195
反应条件
1: 95 percent / BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 15 min, 2.) r.t., 2 h
2: 1.) NaOMe / 1.) DMF, r.t., 12 h, 2.) r.t., 48 h
3: 1.) CuI, TMEDA, 2.) TMSCl / 1.) THF, -78 deg C, 15 min, -30 deg C, 24 h
4: 86 percent / AlCl3 / toluene / 16 h / 90 °C
View Scheme
参考文献
Van Heerden, Pieter S.; Bezuidenhoudt, Barend C. B.; Ferreira, Daneel
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 8 p. 1141 - 1146
反应条件
1: 1.) NaOMe / 1.) DMF, r.t., 12 h, 2.) r.t., 48 h
2: 1.) CuI, TMEDA, 2.) TMSCl / 1.) THF, -78 deg C, 15 min, -30 deg C, 24 h
3: 86 percent / AlCl3 / toluene / 16 h / 90 °C
View Scheme
参考文献
Van Heerden, Pieter S.; Bezuidenhoudt, Barend C. B.; Ferreira, Daneel
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 8 p. 1141 - 1146
