3-(4'-溴[1,1'-联苯]-4-基)-3,4-二氢萘并醛烯-1(2H)-酮合成路线 (共 15 条)
反应条件
1: 1.) CuI, TMEDA, 2.) TMSCl / 1.) THF, -78 deg C, 15 min, -30 deg C, 24 h
2: 86 percent / AlCl3 / toluene / 16 h / 90 °C
View Scheme
参考文献
Van Heerden, Pieter S.; Bezuidenhoudt, Barend C. B.; Ferreira, Daneel
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 8 p. 1141 - 1146
反应条件
1: 1.) CuI, TMEDA, 2.) TMSCl / 1.) THF, -78 deg C, 15 min, -30 deg C, 24 h
2: 86 percent / AlCl3 / toluene / 16 h / 90 °C
View Scheme
参考文献
Van Heerden, Pieter S.; Bezuidenhoudt, Barend C. B.; Ferreira, Daneel
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 8 p. 1141 - 1146
反应条件
1: (i) NaH, DMF, (ii) /BRN= 2280728/, (iii) aq. NaOH, EtOH
2: polyphosphoric acid / 160 - 170 °C
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参考文献
Shadbolt; Woodward; Birchwood
Journal of the Chemical Society. Perkin transactions 1, 1976 , # 11 p. 1190 - 1195
反应条件
1: PBr3
2: (i) NaH, DMF, (ii) /BRN= 2280728/, (iii) aq. NaOH, EtOH
3: polyphosphoric acid / 160 - 170 °C
View Scheme
参考文献
Shadbolt; Woodward; Birchwood
Journal of the Chemical Society. Perkin transactions 1, 1976 , # 11 p. 1190 - 1195
反应条件
1: 85 percent / NaBH4 / ethanol / 2 h / 20 °C
2: PBr3 / CH2Cl2 / 1 h / -10 °C
View Scheme
参考文献
Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531