反应条件
1: With sodium hydroxide; potassium hydrogensulfate in methanol T=0 - 2°C; Hydrolysis; pH=7.15; 0.333333 h; 2: With sodium hydroxide; potassium hydrogensulfate in acetonitrile T=20°C; Substitution; 1 h; 3: With glucose dehydrogenase; beef liver glutamate dehydrogenase; nicotinamide adenine dinucleotide in water T=30°C; reductive amination; pH=8.75; 25 h; Enzymatic reaction;
参考文献
Hanson, Ronald L.; Schwinden, Mark D.; Banerjee, Amit; Brzozowski, David B.; Chen, Bang-Chi; Patel, Bharat P.; McNamee, Clyde G.; Kodersha, Gus A.; Kronenthal, David R.; Patel, Ramesh N.; Szarka, Laszlo J.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 10 p. 2247 - 2252
