2-氨基-4-(三氟甲基)-1,3-苯并噻唑合成路线 （共 3 条）
反应条件
sulfuric acid; bromine T=90°C; 5 h;
参考文献
Hays; Rice; Ortwine; Johnson; Schwarz; Boyd; Copeland; Vartanian; Boxer
Journal of Pharmaceutical Sciences, 1994 , vol. 83, # 10 p. 1425 - 1432
反应条件
1: 27 percent / conc. HCl / H2O / 4 h / Heating 2: 31 percent / conc. H2SO4, Br2 / 5 h / 90 °C View Scheme
参考文献
Journal of Pharmaceutical Sciences, , vol. 83, # 10 p. 1425 - 1432
反应条件
phosphoric acid; hypophosphorous ether; sodium nitrite 1.) water, 0 deg C, 30 min, 2.) RT; Yield given. Multistep reaction;
参考文献
Mylari; Larson; Beyer; Zembrowski; Aldinger; Dee; Siegel; Singleton
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 108 - 122
