反应条件
1: 1.) O2, 2.) H2 / 2.) PtO2*H2O / 1.) CH2Cl2/pyridine, irradiation, 14 h, 15 deg C, 2.) ethyl acetate, room temperature, atmospheric pressure, 10 h 2: 74 percent / calcium hydride, tetra-n-butylammonium iodide / toluene / Heating 3: 59 percent / azobis(isobutyronitrile), SO2Cl2 / CCl4 / 2.5 h / -10 °C / Irradiation 4: 1.) DBU, 2.) ozone / 1.) 150 min, 90 deg C, 2.) CH2Cl2/methanol, -78 deg C 5: 86 percent / 0.15 M aqueous LiOH / tetrahydrofuran / 4 h / Heating 6: 1.) pyridinium chlorochromate, sodium acetate, 2.) 0.15 M aqueous LiOH / 1.) CH2Cl2, 1 h, room temperature, 2.) THF, 5 min, room temperature View Scheme
参考文献
Welzel; Hobert; Ponty; Milkova
Tetrahedron Letters, 1983 , vol. 24, # 31 p. 3199 - 3202
