α-氨基异丁酸苄酯 盐酸盐合成路线 （共 3 条）
反应条件
hydrogenchloride in diethyl ether
T=0°C; 16 h;
参考文献
VALEANT RESEARCH and DEVELOPMENT
Patent: WO2006/121820 A1, 2006 ;
Location in patent: Page/Page column 15-16 ;
反应条件
hydrogenchloride in 1,4-dioxane
T=20°C;
参考文献
Kissei Pharmaceutical Co., Ltd.
Patent: EP1544208 A1, 2005 ;
Location in patent: Page/Page column 62-63 ;
反应条件
1: With toluene-4-sulfonic acid in toluene
6 - 24 h; Heating / reflux;
2: With potassium carbonate in dichloromethane; water
3: With hydrogenchloride in water; acetone
参考文献
Roche Palo Alto LLC
Patent: US2007/42988 A1, 2007 ;
Location in patent: Page/Page column 18; 21 ;
