(S)-(-)-2,2-二甲基-1,3-二氧戊环-4-羧酸甲酯合成路线 （共 17 条）
反应条件
sodium hydroxide; Soerensen phosphate buffer; thermitase in water T=33°C; 1.73333 h; kinetic resolution; Product distribution;
参考文献
Liebigs Annalen der Chemie, , # 1 p. 103 - 104
反应条件
diisobutylaluminium hydride in hexane T=-78°C; 5 h;
参考文献
Ajinomoto Co., Inc.
Patent: EP1574515 A2, 2005 ;
Location in patent: Page/Page column 16 ;
反应条件
lithium hydroxide hydrate in methanol T=20°C; 16 h;
参考文献
BETA INNOV; CLARION, Ludovic; MERSEL, Marcel; PETITE, Didier
Patent: WO2013/168096 A1, 2013 ;
Location in patent: Page/Page column 25 ;
反应条件
N,N-bis-2-(hydroxyethyl)-2-amino ethane sulfonic acid; esterase from Pseudomonas fluorescens in water T=25°C; pH=7.20; Enzyme kinetics;
参考文献
Liu, Andrew Man Fai; Somers, Neil A.; Kazlauskas, Romas J.; Brush, Terry S.; Zocher, Frank; Enzelberger, Markus M.; Bornscheuer, Uwe T.; Horsman, Geoff P.; Mezzetti, Alessandra; Schmidt-Dannert, Claudia; Schmid, Rolf D.
Tetrahedron Asymmetry, 2001 , vol. 12, # 4 p. 545 - 556
反应条件
hydrogenchloride; methanol 1 h; Ambient temperature;
参考文献
Bhatia, Suresh K.; Hajdu, Joseph
Journal of Organic Chemistry, 1988 , vol. 53, # 21 p. 5034 - 5039
反应条件
1: 79 percent / DIBALH / diethyl ether / 0 °C 2: tetra-n-butylammonium hydrogen sulfate; sodium hydroxide / benzene / 45 °C View Scheme
参考文献
Kotsovolou, Stavroula; Verger, Robert; Kokotos, George
Organic letters, 2002 , vol. 4, # 16 p. 2625 - 2628
反应条件
lithium aluminium tetrahydride in diethyl ether 1 h; Ambient temperature;
参考文献
Wilde, H. De; Clercq, P. De; Vandewalle, M.; Roeper, H.
Tetrahedron Letters, 1987 , vol. 28, # 40 p. 4757 - 4758
