(R)-(-)-丁酸缩水甘油酯合成路线 （共 24 条）
反应条件
sodium hydroxide 12 h; Reflux;
参考文献
Jiang, Chengjun; Yan, Jianbo
Letters in Organic Chemistry, 2011 , vol. 8, # 4 p. 242 - 243
反应条件
Jacobsen's (S,S)-(salen)Co(III) catalyst; air; acetic acid in tetrahydrofuran T=0 - 20°C;
参考文献
Schaus, Scott E.; Brandes, Bridget D.; Larrow, Jay F.; Tokunaga, Makoto; Hansen, Karl B.; Gould, Alexandra E.; Furrow, Michael E.; Jacobsen, Eric N.
Journal of the American Chemical Society, 2002 , vol. 124, # 7 p. 1307 - 1315
反应条件
Jacobsen's (S,S)-(salen)Co(III) catalyst; air; acetic acid in tetrahydrofuran T=0 - 20°C;
参考文献
Journal of the American Chemical Society, , vol. 124, # 7 p. 1307 - 1315
反应条件
hydrogenchloride; (R,R)-[Co(salen)]2*GaCl3 in diethyl ether T=0 - 4°C; 4 h;
参考文献
Journal of Organometallic Chemistry, , vol. 691, # 9 p. 1862 - 1872
反应条件
triethylamine; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=0 - 20°C; 1 h; Product distribution / selectivity;
参考文献
WO2006/19202 A1, ;
Page/Page column 6-7; 9 ;
反应条件
sodium phosphate buffer; 25 kDa lipase-like enzyme immobilized on DEAE-Sepharose in 1,4-dioxane; water T=25°C; pH=7.00; 10 h;
参考文献
Palomo, Jose M.; Segura, Rosa L.; Mateo, Cesar; Terreni, Marco; Guisan, Jose M.; Fernandez-Lafuente, Roberto
Tetrahedron Asymmetry, 2005 , vol. 16, # 4 p. 869 - 874
反应条件
(S,S)-(salen)Co(OAc) complex; water in tetrahydrofuran T=0°C; Jacobsen rearrangement; 12 h; optical yield given as percent ee;
参考文献
Jiang, Chengjun; Yan, Jianbo
Letters in Organic Chemistry, 2011 , vol. 8, # 4 p. 242 - 243
反应条件
Rhizopus oryzae lipase on dextran sulfate coated Sepabeads in water T=25°C; pH=7; Enzymatic reaction; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 15, # 7 p. 1157 - 1161
反应条件
Rhizopus oryzae lipase/polystyrene fibers T=35°C; 1 h; Kinetics;
参考文献
Catalysis Communications, , vol. 11, # 6 p. 576 - 580
反应条件
lithium tert-butylate in tetrahydrofuran; methanol; N,N-dimethyl-formamide T=0 - 20°C; 3 h;
参考文献
LegoChem Biosciences, Inc.; CHO, Young Lag; BAEK, Sung Yoon; CHAE, Sang Eun; KIM, Sun Young; LEE, Hong Bum; LEE, Hyang Sook; OH, Kyuman; HEO, Hye Jin; PARK, Tae Kyo; WOO, Sung Ho; KIM, Yong Zu
Patent: EP2692727 A2, 2014 ;
Location in patent: Paragraph 0161-0162 ;
