5,6,11,12-四氢二苯并[b,f]氮杂环辛酮合成路线 （共 4 条）
反应条件
Eaton’s reagent T=100°C; 0.5 h; Inert atmosphere;
参考文献
Chadwick, Ryan C.; Van Gyzen, Sabrina; Liogier, Sophie; Adronov, Alex
Synthesis (Germany), 2014 , vol. 46, # 5 p. 669 - 677
反应条件
trimethylsilylazide; diphenyl phosphoryl azide; water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; iron(II) chloride in acetic acid; trifluoroacetic acid T=80°C; 48 h; Inert atmosphere;
参考文献
Qin, Chong; Zhou, Wang; Chen, Feng; Ou, Yang; Jiao, Ning
Angewandte Chemie - International Edition, 2011 , vol. 50, # 52 p. 12595 - 12599
反应条件
1: pyridine; hydroxylamine hydrochloride / ethanol / 15 h / |Reflux 2: Eaton’s reagent / 0.5 h / 100 °C / |Inert atmosphere View Scheme
参考文献
Synthesis (Germany), , vol. 46, # 5 p. 669 - 677
反应条件
1: 1) NaH / 1) DMF, 60-70 deg C, 1 h, 2) 80 deg C, overnight 2: NaOH / ethanol; H2O / 2 h / Heating View Scheme
参考文献
DeRuiter, Jack; Swearingen, Blake E.; Wandrekar, Vinay; Mayfield, Charles A.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1033 - 1038
