(苯甲酰基甲基)三苯基溴化膦合成路线 （共 33 条）
反应条件
1: sodium hydroxide / water 2: 226.84 °C / Pyrolysis View Scheme
参考文献
Al-Bashir, Rasha F.; Al-Awadi, Nouria A.; El-Dusouqui, Osman M. E.
Journal of Physical Organic Chemistry, 2011 , vol. 24, # 4 p. 311 - 319
反应条件
potassium hydride 1.) DMSO, 1.5 h, 2.) DMSO, overnight; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Ruder, Suzanne M.
Phosphorus, Sulfur and Silicon and the Related Elements, 1994 , vol. 90, # 1-4 p. 53 - 58
反应条件
1: (2-Oxo-2-phenylethyl)triphenylphosphonium bromide With sodium hydroxide in dichloromethane 2: acetaldehyde Wittig reaction; 1 h; Further stages.;
参考文献
Therkelsen, Frans D.; Hansen, Anne-Lene L.; Pedersen, Erik B.; Nielsen, Claus
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 16 p. 2908 - 2918
反应条件
triethylamine in tetrahydrofuran; N,N-dimethyl-formamide T=0 - 80°C; 3.25 h;
参考文献
Bizet, Vincent; Pannecoucke, Xavier; Renaud, Jean-Luc; Cahard, Dominique
Journal of Fluorine Chemistry, 2013 , vol. 152, p. 56 - 61
反应条件
1: 84 percent / I2, K2CO3 / methanol / 1) 0 - 5 deg C, 2h, 2) RT, 4h
2: 60 percent / K2CO3 / methanol / 6 h / 60 °C
View Scheme
参考文献
Iman, Manoutcher; Bouyssou, Pascal; Chenault, Jacques
Synthesis, 1990 , # 7 p. 631 - 632
反应条件
1: (2-Oxo-2-phenylethyl)triphenylphosphonium bromide With sodium hydroxide in dichloromethane; water
T=20°C; 14 h;
2: 3-phenyl-propionaldehyde in dichloromethane
T=20°C; Wittig reaction; 1 h;
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4381297 A1, 1983 ;
US 4381297 A
反应条件
1: 4-methoxy-benzaldehyde With sodium ethanolate in toluene
T=25°C; 0.25 h; Inert atmosphere;
2: (2-Oxo-2-phenylethyl)triphenylphosphonium bromide in toluene
T=80°C; Wittig reaction; 6 h;
参考文献
Bera, Rabin; Dhananjaya; Singh, Shambu Nath; Kumar, Rajender; Mukkanti; Pal, Manojit
Tetrahedron, 2009 , vol. 65, # 7 p. 1300 - 1305
反应条件
potassium hydride
1.) MeOH, 1.5 h, 2.) MeOH, overnight; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Ruder, Suzanne M.
Phosphorus, Sulfur and Silicon and the Related Elements, 1994 , vol. 90, # 1-4 p. 53 - 58
反应条件
1: triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 0 - 80 °C
2: diisobutylaluminium hydride / dichloromethane / 0 °C
3: tris(triphenylphosphine)ruthenium(II) chloride; caesium carbonate / toluene / 3 h / 30 °C / Inert atmosphere
View Scheme
参考文献
Bizet, Vincent; Pannecoucke, Xavier; Renaud, Jean-Luc; Cahard, Dominique
Journal of Fluorine Chemistry, 2013 , vol. 152, p. 56 - 61
反应条件
1: 90 percent / aq. NaOH / methanol / 20 °C
2: 56 percent / benzene / Heating
View Scheme
参考文献
Babu, K. Suresh; Li, Xing-Cong; Jacob, Melissa R.; Zhang, Qifeng; Khan, Shabana I.; Ferreira, Daneel; Clark, Alice M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7877 - 7886
