2,3-吡啶二甲酸二甲酯合成路线 （共 24 条）
参考文献
Kirpal
Monatshefte fuer Chemie, 1899 , vol. 20, p. 768
反应条件
hydrogen; palladium on activated charcoal in methanol P=2585.7 Torr; 16 h;
参考文献
Moss, Neil; Beaulieu, Pierre; Duceppe, Jean-Simon; Ferland, Jean-Marie; Gauthier, Jean; Ghiro, Elise; Goulet, Sylvie; Guse, Ingrid; Llinas-Brunet, Montse; Plante, Raymond; Plamondon, Louis; Wernic, Dominik; Deziel, Robert
Journal of Medicinal Chemistry, 1996 , vol. 39, # 11 p. 2178 - 2187
反应条件
1.1: ethanol; calcium chloride; sodium tetrahydroborate / 16 h / 5 - 20 °C / Inert atmosphere 1.2: 1 h / 20 °C 1.3: Cooling with ice 2.1: thionyl chloride / 16 h / 5 - 20 °C / Inert atmosphere View Scheme
参考文献
Zhang, Han-Cheng; Maryanoff, Bruce; White, Kimberly; Yabut, Stephen C.; Ye, Hong; Chen, Cailin
Patent: US2011/105490 A1, 2011 ;
US 20110105490 A1
反应条件
in methanol Hydrolysis;
参考文献
Journal of Heterocyclic Chemistry, , vol. 36, # 4 p. 979 - 984
反应条件
ammonia; ammonium chloride
参考文献
Spiessens, Luc I. M.; Anteunis, Marc J. O.
Bulletin des Societes Chimiques Belges, 1980 , vol. 89, # 3 p. 205 - 232
反应条件
1: sodium tetrahydroborate; hydrogenchloride / ethanol 2: thionyl chloride / toluene 3: 2-toluenesulfonamide; sodium hydride / N,N-dimethyl-formamide View Scheme
参考文献
Sperry, Jeffrey B.; Farr, Roger M.; Levent, Mahmut; Ghosh, Mousumi; Hoagland, Steven M.; Varsolona, Richard J.; Sutherland, Karen
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1854 - 1860
反应条件
1: 70 percent / m-chloroperbenzoic acid / CHCl3 / 8 h / Heating 2: 1.) hydrazine hydrate, 2.) hydrochloric acid / 1.) methanol, reflux, 30 min, 2.) water, heating, 24 h 3: 51 percent / 30percent hydrogen peroxide, acetic acid / 3 h / 95 °C View Scheme
参考文献
Paul, D. Brenton
Australian Journal of Chemistry, 1984 , vol. 37, # 1 p. 87 - 94
反应条件
1: 95 percent / NH4Cl, liquid ammonia
2: 15 percent / thionyl chloride / dimethylformamide / 3 h / 45 °C
View Scheme
参考文献
Spiessens, Luc I. M.; Anteunis, Marc J. O.
Bulletin des Societes Chimiques Belges, 1980 , vol. 89, # 3 p. 205 - 232
反应条件
1: 70 percent / m-chloroperbenzoic acid / CHCl3 / 8 h / Heating
2: 1.) hydrazine hydrate, 2.) hydrochloric acid / 1.) methanol, reflux, 30 min, 2.) water, heating, 24 h
View Scheme
参考文献
Paul, D. Brenton
Australian Journal of Chemistry, 1984 , vol. 37, # 1 p. 87 - 94
反应条件
hydrogenchloride; sodium tetrahydroborate in ethanol
参考文献
Sperry, Jeffrey B.; Farr, Roger M.; Levent, Mahmut; Ghosh, Mousumi; Hoagland, Steven M.; Varsolona, Richard J.; Sutherland, Karen
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1854 - 1860
