1: triethylamine / dichloromethane / 1 h / 25 °C 2: hydrogenchloride / methanol / 1 h / 25 °C View Scheme
参考文献
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; BEAUCAGE, Serge L.; CIESLAK, Jacek
Patent: WO2012/138530 A1, 2012 ;
1: ε-FmocHN-Lys(α-Fmoc)OH With N-ethyl-N,N-diisopropylamine solid phase reaction; 2: With piperidine in N,N-dimethyl-formamide solid phase reaction; 3: 5-dimethylamino-1-naphthalenesulfonyl chloride Further stages;
