2-(2,4-二硝基-苯氧基)-异吲哚-1,3-二酮合成路线 （共 4 条）
反应条件
hydrazine hydrate in methanol; dichloromethane T=0°C;
参考文献
SIRTRIS PHARMACEUTICALS, INC.
Patent: WO2009/146358 A1, 2009 ;
Location in patent: Page/Page column 87-88 ;
WO 2009/146358 A1
反应条件
triethylamine in acetone
T=20°C; 2 h;
参考文献
SIRTRIS PHARMACEUTICALS, INC.
Patent: WO2009/146358 A1, 2009 ;
Location in patent: Page/Page column 87 ;
WO 2009/146358 A1
反应条件
triethylamine in acetone
T=20°C; 3 h;
参考文献
HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; JIA, Hong; DAI, Guangxiu
Patent: WO2011/79804 A1, 2011 ;
Location in patent: Page/Page column 42 ;
WO 2011/079804 A1
反应条件
triethylamine in acetone
T=4 - 20°C;
参考文献
Tudose, Madalina; Badea, Florin D.; Caproiu, Miron T.; Beteringhe, Adrian; Maganu, Maria; Ionita, Petre; Constantinescu, Titus; Balaban, Alexandru T.
Central European Journal of Chemistry, 2010 , vol. 8, # 4 p. 789 - 796
