6-甲基-2-苯基喹啉-4-羧酸合成路线 （共 9 条）
反应条件
[Yb(PFO)3] in water
Doebner reaction; 3 h; Reflux;
参考文献
Wang, Li-Min; Hu, Liang; Chen, Hong-Juan; Sui, Yuan-Yuan; Shen, Wei
Journal of Fluorine Chemistry, 2009 , vol. 130, # 4 p. 406 - 409
反应条件
potassium hydroxide in ethanol; water
Pfitzinger reaction; 18 h; Heating;
参考文献
Boa, Andrew N.; Canavan, Shane P.; Hirst, Paul R.; Ramsey, Christopher; Stead, Andrew M.W.; McConkey, Glenn A.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 1945 - 1967
反应条件
benzaldehyde in sodium hydroxide; ethanol
参考文献
Mitsui Toatsu Chemicals, Inc.
Patent: US5627193 A1, 1997 ;
US 5627193 A
反应条件
1: sodium sulfate; hydrogenchloride; hydroxylamine hydrochloride / water / 2.5 h / 85 °C
2: sulfuric acid / 60 - 90 °C
3: potassium hydroxide / ethanol / 72.5 h / |Reflux
View Scheme
参考文献
Shi, Zhi-Bing; Zhang, Lei; Bin, Zheng-Yang; Cao, Xiang-Rong; Gong, Zhu-Nan; Li, Jian-Xin
Letters in Drug Design and Discovery, 2013 , vol. 10, # 5 p. 420 - 426
反应条件
1: sulfuric acid / 60 - 90 °C
2: potassium hydroxide / ethanol / 72.5 h / |Reflux
View Scheme
参考文献
Shi, Zhi-Bing; Zhang, Lei; Bin, Zheng-Yang; Cao, Xiang-Rong; Gong, Zhu-Nan; Li, Jian-Xin
Letters in Drug Design and Discovery, 2013 , vol. 10, # 5 p. 420 - 426
反应条件
1: thionyl chloride / 3 h / Heating
2: 16 g / CH2Cl2 / 3 h / Heating
3: 87 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 3 h / Heating
4: 85 percent / 2-nitropropane; sodium / ethanol / 3 h / Heating
View Scheme
参考文献
Boa, Andrew N.; Canavan, Shane P.; Hirst, Paul R.; Ramsey, Christopher; Stead, Andrew M.W.; McConkey, Glenn A.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 1945 - 1967
参考文献
Buchman; Howton
Journal of the American Chemical Society, 1946 , vol. 68, p. 2718
反应条件
1: thionyl chloride / 3 h / Heating
2: 10.4 percent / triethylamine / 3 h / 20 °C
View Scheme
参考文献
Boa, Andrew N.; Canavan, Shane P.; Hirst, Paul R.; Ramsey, Christopher; Stead, Andrew M.W.; McConkey, Glenn A.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 1945 - 1967
参考文献
Kaku
Yakugaku Zasshi, 1930 , vol. 50, p. 235,238; dtsch. Ref. S. 31
Chem.Abstr., 1930 , p. 3511
Full Text Show Details
Fourneau et al.
Ann. Inst. Pasteur, 1930 , vol. 44, p. 719,729
