6-溴苯并[d][1,3]二氧代-5-羧酸合成路线 （共 26 条）
反应条件
aluminium trichloride
参考文献
Tomita et al.
Yakugaku Zasshi, 1956 , vol. 76, p. 1122,1125
Chem.Abstr., 1957 , p. 3505
反应条件
sulfuric acid
3 h; Heating;
参考文献
Brown, Eric; Robin, Jean-Pierre; Dhal, Robert
Tetrahedron, 1982 , vol. 38, # 16 p. 2569 - 2580
反应条件
sulfuric acid in methanol
72 h; Heating;
参考文献
Swenton, John S.; Carpenter, Kenneth; Chen, Ying; Kerns, Michael L.; Morrow, Gary W.
Journal of Organic Chemistry, 1993 , vol. 58, # 12 p. 3308 - 3316
反应条件
1: thionyl chloride / Heating
View Scheme
参考文献
Grimshaw, James; Hamilton, Robert; Trocha-Grimshaw, Jadwiga
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 229 - 234
反应条件
1.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 2.92 h / 0 - 80 °C / |Inert atmosphere
2.1: triethylamine / dichloromethane / 0.08 h / 0 °C / |Inert atmosphere
2.2: 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
De, Subhadip; Ghosh, Santanu; Bhunia, Subhajit; Sheikh, Javeed Ahmad; Bisai, Alakesh
Organic Letters, 2012 , vol. 14, # 17 p. 4466 - 4469
反应条件
1: (COCl)2 / CH2Cl2 / 12 h / Ambient temperature
2: 85 percent / pyridine / benzene / 12 h / Heating
3: 84 percent / Cs2CO3 / tetrahydrofuran; dimethylformamide / 5 h / 80 °C
4: 80 percent / LiClO4 / diethyl ether / 36 h / 100 °C
5: 79 percent / bis(tributyltin) / benzene / 24 h / 80 °C / Irradiation
6: KOH / methanol / 2 h / Heating
7: copper bronze / quinoline / 2.5 h / 220 - 225 °C
View Scheme
参考文献
Grotjahn; Vollhardt
Synthesis, 1993 , # 6 p. 579 - 605
