2-哌嗪基-4-氨基-6,7-二甲氧基喹唑啉合成路线 （共 9 条）
反应条件
hydrogen; triethylamine; palladium on activated charcoal in methanol 6 h; atmospheric pressure;
参考文献
Journal of medicinal chemistry, , vol. 47, # 18 p. 4453 - 4462
反应条件
in 3-methyl-1-butanol 30 h; Reflux;
参考文献
Cavalli, Andrea; Lizzi, Federica; Bongarzone, Salvatore; Brun, Reto; Luise Krauth-Siegel; Bolognesi, Maria Laura
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 11 p. 3031 - 3035
反应条件
1.1: macroporous polymer-supported carbonate / dimethylsulfoxide / 100 °C 1.2: PS-SH; macroporous polymer-supported isocyanate / dimethylsulfoxide / 60 °C 2.1: macroporous polymer-supported-TsOH / CH2Cl2 / 20 °C 2.2: aq. NH3 / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 15 p. 2549 - 2552
反应条件
in dichloromethane; ethyl acetate 2 h;
参考文献
Pitha, Josef; Szabo, Lajos; Szurmai, Zoltan; Buchowiecki, Wieslaw; Kusiak, John W.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 96 - 100
反应条件
in tetrahydrofuran T=25 - 28°C; Product distribution / selectivity;
参考文献
CIPLA LIMITED
Patent: US2012/41199 A1, 2012 ;
Location in patent: Page/Page column 7-8 ;
反应条件
in chloroform; water
反应条件
1: With macroporous polymer-supported carbonate in dichloromethane T=20°C; 2: With PS-Trisamine in dichloromethane
参考文献
Duncton, Matthew A. J.; Roffey, Jonathan R. A.; Hamlyn, Richard J.; Adams, David R.
Tetrahedron Letters, 2006 , vol. 47, # 15 p. 2549 - 2552
参考文献
Mitsubishi Yuka Pharmaceutical Co., Ltd.
Patent: US4607034 A1, 1986 ;
