2-氨基-4-苄氧基-5-甲氧基苯甲酰胺合成路线 （共 14 条）
反应条件
1.1: potassium permanganate / acetone / 2 h / 30 - 50 °C
2.1: oxalyl dichloride / toluene / 2 h / Reflux
2.2: 2 h
3.1: acetic acid / 0.17 h / 90 °C
3.2: 1 h / Reflux
View Scheme
参考文献
HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup
Patent: WO2012/30160 A2, 2012 ;
反应条件
1.1: nitric acid / 2 h / 0 - 20 °C
2.1: potassium permanganate / acetone / 2 h / 30 - 50 °C
3.1: oxalyl dichloride / toluene / 2 h / Reflux
3.2: 2 h
4.1: acetic acid / 0.17 h / 90 °C
4.2: 1 h / Reflux
View Scheme
参考文献
HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup
Patent: WO2012/30160 A2, 2012 ;
反应条件
1.1: dioxane / 24 h / Heating
1.2: 84 percent / NaOAc; AcOH / 3 h / Heating
2.1: NaH / dimethylformamide / 1.5 h
2.2: 84 percent / dimethylformamide / 2 h / 20 °C
View Scheme
参考文献
Hennequin, Laurent F.; Thomas, Andrew P.; Johnstone, Craig; Stokes, Elaine S. E.; Ple, Patrick A.; Lohmann, Jean-Jacques M.; Ogilvie, Donald J.; Dukes, Mike; Wedge, Steve R.; Curwen, Jon O.; Kendrew, Jane; Lambert-Van Der Brempt, Christine
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5369 - 5389
反应条件
1.1: dioxane / 24 h / Heating
1.2: 84 percent / NaOAc; AcOH / 3 h / Heating
2.1: SOCl2; DMF / Heating
3.1: propan-2-ol / 4 h / Heating
View Scheme
参考文献
HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup
Patent: WO2012/30160 A2, 2012 ;
