2,3-二甲氧基-6-溴苯甲酸合成路线 （共 15 条）
参考文献
Sugasawa
Journal of the Chemical Society, 1933 , p. 1621,1623
Yakugaku Zasshi, 1934 , vol. 54, p. 295,300
Chem.Abstr., 1935 , p. 160
反应条件
1: oxalyl chloride / CH2Cl2 / 1.33 h / Heating
2: 1.01 g / Et3N / CH2Cl2 / 1 h / 20 °C
3: 93 percent / NaH / dimethylformamide / 5 h / 20 °C
4: 96 percent / Ag2CO3 / Pd(OAc)2; P(o-Tol)3 / dimethylformamide / 3 h / Heating
View Scheme
参考文献
Harayama; Akiyama; Akamatsu; Kawano; Abe; Takeuchi
Synthesis, 2001 , # 3 p. 444 - 450
反应条件
1.1: SOCl2 / Heating
2.1: Et3N; DMAP / CH2Cl2 / 20 °C
3.1: KHMDS / toluene / 0 - 20 °C
3.2: 47 percent / toluene
4.1: 90 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0 °C
5.1: 77 percent / PPh3; aq. NaOH / Pd(OAc)2 / tetrahydrofuran / Heating
6.1: H2 / Pd/C / methanol / 20 °C
7.1: 60 percent / H2SO4 / acetic acid / 20 °C
8.1: 65 percent / H2 / Pd/C / acetic acid / 20 °C
View Scheme
参考文献
Fuchs, James R.; Funk, Raymond L.
Organic Letters, 2001 , vol. 3, # 24 p. 3923 - 3925
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 4 h;
参考文献
Konno, Fujiko; Ishikawa, Tsutomu; Kawahata, Masatoshi; Yamaguchi, Kentaro
Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9818 - 9823
反应条件
thionyl chloride in benzene
1 h; Heating;
参考文献
Nimgirawath, Surachai; Ponghusabun, Ong-ard
Australian Journal of Chemistry, 1994 , vol. 47, # 5 p. 951 - 956
