2-(溴甲基)-5-氯-吡啶(9ci)合成路线 （共 5 条）
反应条件
phosphorus tribromide in dichloromethane T=20°C; 1 h;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.; GRADL, Stefan; LAIRD, Ellen; MORENO, David; REN, Li; WENGLOWSKY, Steven Mark
Patent: WO2011/25968 A1, 2011 ;
Location in patent: Page/Page column 42 ;
WO 2011/025968 A1
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane 5.5 h; Heating / reflux;
参考文献
MERCK and CO., INC.
Patent: WO2005/44785 A1, 2005 ;
Location in patent: Page/Page column 67-68 ;
WO 2005/044785 A1
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 1.2: 0 - 20 °C 2.1: phosphorus tribromide / dichloromethane / 1 h / 20 °C View Scheme
参考文献
WO2011/25968 A1, ;
WO 2011/025968 A1
反应条件
1: sodium tetrahydroborate; methanol / 2.5 h / 0 - 20 °C 2: triphenylphosphine; carbon tetrabromide / dichloromethane / 3.5 h / 0 - 20 °C View Scheme
反应条件
1: palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine / 24 h / 50 °C / 775.74 Torr 2: sodium tetrahydroborate; methanol / 2.5 h / 0 - 20 °C 3: triphenylphosphine; carbon tetrabromide / dichloromethane / 3.5 h / 0 - 20 °C View Scheme
