5-氨基-1-苄基-1H-咪唑-4-甲腈合成路线 （共 16 条）
反应条件
1.1: 90 percent / TFA / 5 h / Heating 2.1: MeONa / methanol / 0.33 h / 0 °C 2.2: 70 percent / anilinium chloride / 20 h / 20 °C View Scheme
参考文献
Hosmane, Ramachandra S.; Lim, Benjamin B.; Burnett, Friedrich N.
Journal of Organic Chemistry, 1988 , vol. 53, # 2 p. 382 - 386
反应条件
1: With aniline hydrochloric acid in ethanol
T=10 - 20°C; 18 h;
2: With sodium hydroxide in ethanol; water
T=10 - 20°C; 18 h;
参考文献
PFIZER LIMITED
Patent: WO2006/117670 A1, 2006 ;
Location in patent: Page/Page column 59 ;
反应条件
triethylamine; trichlorophosphate in dichloromethane
T=-5°C; 2 h;
参考文献
Costanzi, Stefano; Rouse, Sean P.N.; Vanbaelinghem, Laurence; Prior, Timothy J.; Ewing, David F.; Boa, Andrew N.; MacKenzie, Grahame
Tetrahedron Letters, 2012 , vol. 53, # 4 p. 412 - 415
反应条件
aniline hydrochloric acid in ethanol
T=10 - 20°C;
参考文献
JANSSEN RandD IRELAND; BONFANTI, Jean-François; DOUBLET, Frédéric Marc Maurice; EMBRECHTS, Werner; FORTIN, Jérôme Michel Claude; MC GOWAN, David Craig; MULLER, Philippe; RABOISSON, Pierre Jean-Marie Bernard
Patent: WO2013/68438 A1, 2013 ;
Location in patent: Page/Page column 8 ;
反应条件
in acetonitrile
12 h; Ambient temperature;
参考文献
Hosmane, Ramachandra S.; Lim, Benjamin B.; Burnett, Friedrich N.
Journal of Organic Chemistry, 1988 , vol. 53, # 2 p. 382 - 386
反应条件
potassium carbonate in tetrahydrofuran; N,N-dimethyl-formamide
48 h; Ambient temperature;
参考文献
Grozinger; Freter; Farina; Gladczuk
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 221 - 226
反应条件
2: trifluoroacetic acid / toluene; methanol / Heating
View Scheme
参考文献
Hosmane, Ramachandra S.; Lim, Benjamin B.
Heterocycles, 1988 , vol. 27, # 1 p. 31 - 34
反应条件
potassium carbonate in tetrahydrofuran; N,N-dimethyl-formamide
7 h; Heating;
参考文献
Grozinger; Onan
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 737 - 745
反应条件
trifluoroacetic acid in methanol; toluene
72 h; Heating;
参考文献
Hosmane, Ramachandra S.; Lim, Benjamin B.; Burnett, Friedrich N.
Journal of Organic Chemistry, 1988 , vol. 53, # 2 p. 382 - 386
参考文献
Sourena, Nadji; Smoot, James; Sampath, UmaShanker
Patent: US2004/181052 A1, 2004 ;
Location in patent: Page 10 ;
