5-氨基-1-苄基-1H-咪唑-4-甲腈合成路线 （共 16 条）
反应条件
in ethanol
10 h; Heating;
参考文献
Hirota, Kosaku; Kazaoka, Kazunori; Sajiki, Hironao
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 13 p. 2715 - 2722
反应条件
1.1: 89 percent / aq. hydroxylamine / ethanol / Heating
2.1: sodium; ethanol / 20 °C
2.2: 56 percent / ethanol / Heating
3.1: 36 percent / sodium hydride in oil / dimethylformamide / 0.25 h / 75 - 100 °C
View Scheme
参考文献
Berry, David A.; Chien, Tun-Cheng; Townsend, Leroy B.
Heterocycles, 2004 , vol. 63, # 11 p. 2475 - 2494
反应条件
1: pyridine / 1 h / Heating
2: 87 percent / 10percent Na2HPO4 / 0.08 h
View Scheme
参考文献
Grozinger; Freter; Farina; Gladczuk
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 221 - 226
反应条件
N-bromosuccinmide in tetrahydrofuran
T=20°C; 0.166667 h;
参考文献
Hirota, Kosaku; Kazaoka, Kazunori; Niimoto, Itaru; Sajiki, Hironao
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 8 p. 1354 - 1365
反应条件
N-chloro-succinimide in tetrahydrofuran
T=20°C; 10 h;
参考文献
Hirota, Kosaku; Kazaoka, Kazunori; Sajiki, Hironao
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 13 p. 2715 - 2722
反应条件
1: 84 percent / trifluoroacetic acid / 4 h / Heating
2: 81 percent / hydrazine monohydrate / methanol / 12 h / Ambient temperature
View Scheme
参考文献
Hosmane, Ramachandra S.; Lim, Benjamin B.; Burnett, Friedrich N.
Journal of Organic Chemistry, 1988 , vol. 53, # 2 p. 382 - 386
