反应条件
1: 1.) 75percent H2O2,trifluoroacetic anhydride, 2.) KOH / 1.) CH2Cl2, -40 deg C, 20 min, 2.) MeOH, reflux, 30 min
2: 97 percent / K2CO3 / acetone / 22 h / Heating
3: 92 percent / Br2 / CH2Cl2 / -10 °C
4: 1.) n-BuLi / 1.) Et2O, 30 min, 2.) Et2O, 1 h, low temperature, 10 h, room temperature, 3 h, reflux
5: 83 percent / Br2 / CH2Cl2 / 3 - 5 °C
7: PTA, CAN / acetonitrile; H2O / 0.33 h
View Scheme
参考文献
Syper, L.; Kloc, K.; Mlochowski, J.
Tetrahedron, 1980 , vol. 36, # 1 p. 123 - 129
