2-氨基-3-硝基苯甲酸合成路线 （共 76 条）
反应条件
1: hydrogenchloride / water / 12 h / |Reflux; |Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / methanol / 8 h / |Inert atmosphere 3: water / 0.75 h / |Reflux; |Inert atmosphere View Scheme
参考文献
Wang, Jingjing; Zuo, Sujing; Chen, Weiqiang; Zhang, Xinrui; Tan, Kaixin; Tian, Yun; Wang, Jianhui
Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8217 - 8231
反应条件
1: SOCl2 / tetrahydrofuran; dimethylformamide / 20 °C 2: conc. aq. NH3 / tetrahydrofuran; dimethylformamide 3: H2 / 10percent Pd/C / methanol / 760.05 Torr View Scheme
参考文献
Bayer CropScience AG; The designation of the inventor has not yet been filed
Patent: EP2561759 A1, 2013 ;
反应条件
1: 2-methoxy-ethanol / 24 h / Heating 2: phosphorus oxychloride; phosphorus pentachloride; formamide / 3 h / Heating 3: CH2Cl2 / 16 h / 20 °C 4: H2 / Pd/C / ethanol / 41 h / 20 °C / atmospheric pressure 5: 0.69 g / aq. NaOH / ethanol / 3 h / Heating View Scheme
参考文献
Elderfield; Dodd; Gensler
Journal of Organic Chemistry, 1947 , vol. 12, p. 393,399
反应条件
1: 1.) DCC, HOBT, 4-methylmorpholine / 1.) THF, 2.) THF, DMF, 24 h 2: LiAlH4 / dioxane / 48 h / Heating View Scheme
参考文献
Breslin; Kukla; Ludovici; Mohrbacher; Ho; Miranda; Rodgers; Hitchens; Leo; Gauthier; Scott; De Clercq; Pauwels; Andries; Janssen
Journal of Medicinal Chemistry, 1995 , vol. 38, # 5 p. 771 - 793
反应条件
thionyl chloride in methanol T=0°C; 23 h; Heating / reflux;
参考文献
NIPPON CHEMIPHAR CO., LTD.
Patent: EP1452528 A1, 2004 ;
Location in patent: Page 21-22 ;
反应条件
1: 2-Amino-3-nitro-benzoic acid With lithium hydroxide hydrate T=20°C; 1 h; 2: dimethyl sulfate in tetrahydrofuran 24 h; Reflux;
参考文献
GRUeNENTHAL GMBH; SCHUNK, Stefan; REICH, Melanie; ENGELS, Michael; GERMANN, Tieno; DE VRY, Jean; JOSTOCK, Ruth; HEES, Sabine
Patent: WO2010/142402 A1, 2010 ;
Location in patent: Page/Page column 109-110 ;
反应条件
hydrogenchloride in methanol
参考文献
Newcastle University Ventures Limited
Patent: US6100283 A1, 2000 ;
反应条件
in methanol; diethyl ether T=20°C;
参考文献
CHEMOCENTRYX, INC.
Patent: WO2007/51062 A2, 2007 ;
Location in patent: Page/Page column 132 ;
WO 2007/051062 A2
参考文献
MERCK SERONO S.A.; THUNUGUNTLA, Siva Sanjeeva Rao; SUBRAMANYA, Hosahalli; KUNNAM, Satish Reddy; SANIVARU VIJAY, Sekhar Reddy; BINGI, Chakrapani; KUSANUR, Raviraj; SCHWARZ, Matthias; ARLT, Michael
Patent: WO2010/115736 A2, 2010 ;
Location in patent: Page/Page column 62 ;
WO 2010/115736 A2
反应条件
1: 66 percent / H2 / 10percent Pd/C / methanol / 760.05 Torr 2: 44 percent / Cu(OAc)2 / methanol; H2O / Heating View Scheme
参考文献
White; Almassy; Calvert; Curtin; Griffin; Hostomsky; Maegley; Newell; Srinivasan; Golding
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4084 - 4097
