2-氨基-3-硝基苯甲酸合成路线 （共 76 条）
反应条件
1: 60 percent / HCl(g) / 6 h / Heating 2: 64 percent / Et3N / tetrahydrofuran / 12 h / 20 °C 3: 75 percent / H2 / 10percent Pd/C / methanol / 760.05 Torr View Scheme
参考文献
White; Almassy; Calvert; Curtin; Griffin; Hostomsky; Maegley; Newell; Srinivasan; Golding
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4084 - 4097
反应条件
1: diethyl ether / 0 °C 2: 96 percent / hydrogen / Pd/C / methanol / 3 h View Scheme
参考文献
White; Almassy; Calvert; Curtin; Griffin; Hostomsky; Maegley; Newell; Srinivasan; Golding
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4084 - 4097
反应条件
1: 97 percent / N-methylmorpholine, hydroxybenztriazole, dicyclohexylcarbodiimide / tetrahydrofuran / 1.) -12 deg C, 5.5 h, 2.) RT, 16 h 2: H2 / 10percent Pd/C / ethanol / 4 h / 2327.2 Torr 3: 0.67 h / 200 °C 4: lithium aluminum hydride / dioxane / 45 h / 100 °C 5: 1.) N-methylmorpholine / 1.) a) CH2Cl2, 0 deg C, 10 min, b) 20 deg C, 20 min, 2.) H2O, dioxane, 100 deg C, 45 min 6: 34 percent / potassium iodide, sodium carbonate / dimethylformamide / 22.5 h / Ambient temperature View Scheme
参考文献
Kukla, Michael J.; Breslin, Henry J.; Pauwels, Rudi; Fedde, Cynthia L.; Miranda, Milton; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 746 - 751
反应条件
1: 97 percent / N-methylmorpholine, hydroxybenztriazole, dicyclohexylcarbodiimide / tetrahydrofuran / 1.) -12 deg C, 5.5 h, 2.) RT, 16 h 2: H2 / 10percent Pd/C / ethanol / 4 h / 2327.2 Torr 3: 0.67 h / 200 °C 4: lithium aluminum hydride / dioxane / 45 h / 100 °C 5: 1.) N-methylmorpholine / 1.) a) CH2Cl2, 0 deg C, 10 min, b) 20 deg C, 20 min, 2.) H2O, dioxane, 100 deg C, 45 min 6: 42 percent / potassium iodide, sodium carbonate / dimethylformamide / 22.5 h / Ambient temperature View Scheme
参考文献
Kukla, Michael J.; Breslin, Henry J.; Pauwels, Rudi; Fedde, Cynthia L.; Miranda, Milton; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 746 - 751
反应条件
Pd-on-charcoal in ethanol
参考文献
Bayer Aktiengesellschaft
Patent: US5545646 A1, 1996 ;
反应条件
1: H2, aq. NaOH / Pd/C 2: cupric acetate, AcOH / H2O; methanol / Heating 3: 1.) 1,1'-carbonyldiimidazole / 1.) DMF, 40 deg C, 5 min, 2.) 10 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 2 p. 814 - 819
反应条件
1: H2, aq. NaOH / Pd/C 2: cupric acetate, AcOH / H2O; methanol / Heating View Scheme
参考文献
Xue, Fei; Luo, Xianjin; Ye, Chenghao; Ye, Weidong; Wang, Yue
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 8 p. 2641 - 2649
反应条件
1: NaOH; hydrazine hydrate; Raney Ni 2: K3Fe(CN)6 / methanol / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 2 p. 267 - 269
反应条件
1: NaOH; hydrazine hydrate; Raney Ni 2: K3Fe(CN)6 / methanol / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 2 p. 267 - 269
反应条件
1: 66 percent / H2 / 10percent Pd/C / methanol / 760.05 Torr 2: 48 percent / Cu(OAc)2 / methanol; H2O / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 22 p. 4084 - 4097
