反应条件
1: 82 percent / dimethylformamide / 2 h / 140 - 150 °C 2: 71 percent / hydrochloric acid, iron / methanol; dioxane / 0.5 h / Heating 3: 1.) sodium nitrite, sulfuric acid, 2.) copper(I) bromide, aq. hydrochloric acid / 1.) acetic acid, 40 deg C, 30 min, 2.) 65 to 90 deg C 4: 78 percent / iron, concentrated hydrochloric acid / methanol / 0.17 h View Scheme
参考文献
Harris, Neil V.; Smith, Christopher; Bowden, Keith
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 434 - 444