lithium diisopropyl amide 1.) hexane, THF, -78 deg C, 1 h, 2.) -78 deg C, 10 min; Yield given. Multistep reaction;

1: 3-trifluoromethyl-fluorobenzene With n-butyllithium; N,N,N',N,-tetramethylethylenediamine; diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphere; 2: N,N-dimethyl-formamide T=-78°C; Inert atmosphere; Reagent/catalystTemperatureTime; regioselective reaction;

暂无反应条件数据

sodium hydride 1.) DMSO, 20 deg C, 15 min, 2.) DMSO, 3 min; Yield given. Multistep reaction;

hydroxylamine hydrochloride; potassium carbonate in ethanol T=20°C; 24 h;

sodium hydroxide in methanol; dichloromethane