(9ci)-5-[5-(甲基硫代)-1,3,4-噁二唑-2-基]-1H-苯并咪唑合成路线 （共 4 条）
反应条件
triethylamine in ethanol
Heating / reflux;
参考文献
PROBIODRUG AG
Patent: WO2008/65141 A1, 2008 ;
Location in patent: Page/Page column 62-63 ;
WO 2008/065141 A1
反应条件
1: sulfuric acid / 24 h / |Reflux
2: hydrazine hydrate / ethanol / 48 h / |Reflux
3: potassium hydroxide / ethanol; water / 10 h / |Reflux
4: triethylamine / ethanol / |Reflux
View Scheme
参考文献
Ramsbeck, Daniel; Buchholz, Mirko; Koch, Birgit; Boehme, Livia; Hoffmann, Torsten; Demuth, Hans-Ulrich; Heiser, Ulrich
Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6613 - 6625
反应条件
1: potassium hydroxide / ethanol; water / 10 h / |Reflux
2: triethylamine / ethanol / |Reflux
View Scheme
参考文献
Ramsbeck, Daniel; Buchholz, Mirko; Koch, Birgit; Boehme, Livia; Hoffmann, Torsten; Demuth, Hans-Ulrich; Heiser, Ulrich
Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6613 - 6625
反应条件
1: hydrazine hydrate / ethanol / 48 h / |Reflux
2: potassium hydroxide / ethanol; water / 10 h / |Reflux
3: triethylamine / ethanol / |Reflux
View Scheme
参考文献
Ramsbeck, Daniel; Buchholz, Mirko; Koch, Birgit; Boehme, Livia; Hoffmann, Torsten; Demuth, Hans-Ulrich; Heiser, Ulrich
Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6613 - 6625
