反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 75 °C
2: water; sodium hydroxide / tetrahydrofuran / 2 h
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 48 h / 20 °C
4: hydrogenchloride / ethanol / 24 h
View Scheme
参考文献
NOVARTIS PHARMA AG; AMGEN INC.; HUANG, Xizhong; PETERS, Malte; SCHUMACHER, Karl, Maria; CAO, Zhu, Alexander; GANSERT, Jennifer, Lorraine; CHANG, David, Dong, Eun; BELTRAN, Pedro
Patent: WO2013/142182 A2, 2013 ;
