5-((4-溴-2-氯苯基)氨基)-4-氟-1-甲基-1H-苯并[d]咪唑-6-羧酸合成路线 （共 2 条）
反应条件
1: With sodium hydroxide; water in tetrahydrofuran
2 h;
2: With hydrogenchloride
pH=2;
参考文献
Wallace, Eli M.; Lyssikatos, Joseph P.; Marlow, Allison L.; Hurley, T. Brian
Patent: US2003/232869 A1, 2003 ;
Location in patent: Page 10; 22; 23 ;
US 20030232869 A1
反应条件
1: 6-amino-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid methyl ester With copper(l) iodide in isopropyl alcohol
T=40°C; 0.25 h;
2: With potassium carbonate; ethylene glycol
1 h; Heating / reflux;
3: 4-bromo-2-chloro-1-iodo-benzene With isopropyl alcohol
26 h;
参考文献
ARRAY BIOPHARMA INC.; ASTRAZENECA AB
Patent: WO2007/2157 A2, 2007 ;
Location in patent: Page/Page column 73; 74 ;
WO 2007/002157 A2
