5-羟基-1-甲基-2-吲哚啉酮合成路线 （共 12 条）
反应条件
aluminium trichloride
T=180°C; Friedel-Crafts reaction;
参考文献
Chambers, Robert J.; Abrams, Kristin; Garceau, Norman Y.; Kamath, Ajith V.; Manley, Christopher M.; Lilley, Susan C.; Otte, Douglas A.; Scott, Dennis O.; Sheils, Alissa L.; Tess, David A.; Vellekoop, A. Samuel; Zhang, Yan; Lam, Kelvin T.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 307 - 310
反应条件
chloroacetyl chloride; benzene
Erhitzen des Reaktionsprodukts mit Aluminiumchlorid auf 185grad;
参考文献
Julian et al.
Journal of the American Chemical Society, 1935 , vol. 57, p. 2026,2028
反应条件
1: 83 percent / TEA; DMAP / dimethylformamide / 0 °C
2: 89 percent / AlCl3 / 180 °C
View Scheme
参考文献
Chambers, Robert J.; Abrams, Kristin; Garceau, Norman Y.; Kamath, Ajith V.; Manley, Christopher M.; Lilley, Susan C.; Otte, Douglas A.; Scott, Dennis O.; Sheils, Alissa L.; Tess, David A.; Vellekoop, A. Samuel; Zhang, Yan; Lam, Kelvin T.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 307 - 310
反应条件
hydrogen bromide; acetic acid
6 h; Heating;
参考文献
Rewcastle; Palmer; Dobrusin; Fry; Kraker; Denny
Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 2033 - 2042
反应条件
1: 1.) n-butyllithium, 3.) n-butyllithium, 5.) 0.1 M HCl
2: HBr, glacial AcOH / 6 h / Heating
View Scheme
参考文献
Rewcastle; Palmer; Dobrusin; Fry; Kraker; Denny
Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 2033 - 2042
反应条件
aluminium trichloride
参考文献
Porter et al.
Journal of the Chemical Society, 1941 , p. 620,621
反应条件
glyoxal sodium disulfite; water
beim Zersetzen des Reaktionsprodukts mit siedender verduennter Salzsaeure;
参考文献
Merck,E.
Patent: DE421386 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 15, p. 1732
反应条件
pyridine in dichloromethane
T=0°C;
参考文献
Chambers, Robert J.; Abrams, Kristin; Garceau, Norman Y.; Kamath, Ajith V.; Manley, Christopher M.; Lilley, Susan C.; Otte, Douglas A.; Scott, Dennis O.; Sheils, Alissa L.; Tess, David A.; Vellekoop, A. Samuel; Zhang, Yan; Lam, Kelvin T.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 307 - 310
参考文献
Pfizer Inc.
Patent: US4695571 A1, 1987 ;
反应条件
1: 94 percent / pyridine / CH2Cl2 / 0 °C
2: 76 percent / AlCl3 / 180 °C
View Scheme
参考文献
Chambers, Robert J.; Abrams, Kristin; Garceau, Norman Y.; Kamath, Ajith V.; Manley, Christopher M.; Lilley, Susan C.; Otte, Douglas A.; Scott, Dennis O.; Sheils, Alissa L.; Tess, David A.; Vellekoop, A. Samuel; Zhang, Yan; Lam, Kelvin T.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 307 - 310
