5-(4-羟基苯基)-3-异噁唑羧酸甲酯合成路线 （共 3 条）
反应条件
hydroxylammonium sulphate in methanol
0.25 h; Heating;
参考文献
Hashimoto; Shizu; Takahashi
Chemical and Pharmaceutical Bulletin, 1976 , vol. 24, # 8 p. 1757 - 1764
反应条件
1: NaOMe / methanol
2: aq. NH2OH*0.5 H2SO4 / methanol / 0.25 h / Heating
View Scheme
参考文献
Hashimoto; Shizu; Takahashi
Chemical and Pharmaceutical Bulletin, 1976 , vol. 24, # 8 p. 1757 - 1764
反应条件
1: Et3N / diethyl ether; tetrahydrofuran
2: NaOAc / 2 h / 110 °C
3: Br2 / CCl4 / Ambient temperature
4: (i) acetone, (ii) NaBH4, MeOH
View Scheme
参考文献
Hashimoto; Shizu; Takahashi
Chemical and Pharmaceutical Bulletin, 1976 , vol. 24, # 8 p. 1757 - 1764
