(3S)-3-[[(苯基甲氧基)羰基]氨基]-1,1,3-丙烷三羧酸 1,1-二叔丁酯合成路线 （共 9 条）
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite in phosphate buffer; acetonitrile
T=40°C; pH=6.7; 18 h;
参考文献
Jiang, Sheng; Li, Peng; Lai, Christopher C.; Kelley, James A.; Roller, Peter P.
Journal of Organic Chemistry, 2006 , vol. 71, # 19 p. 7307 - 7314
反应条件
1: 90 percent / H2 / Pd/C / methanol
2: 92 percent / BiBr3 / acetonitrile; H2O / 8 h / 20 °C
3: 92 percent / TEMPO; NaClO2; NaClO / acetonitrile; aq. phosphate buffer / 18 h / 40 °C / pH 6.7
View Scheme
参考文献
Jiang, Sheng; Li, Peng; Lai, Christopher C.; Kelley, James A.; Roller, Peter P.
Journal of Organic Chemistry, 2006 , vol. 71, # 19 p. 7307 - 7314
反应条件
1.1: LDA; HMPA / tetrahydrofuran / -78 °C
1.2: 80 percent / Ac2O; DMAP; pyridine
2.1: 90 percent / H2 / Pd/C / methanol
3.1: 92 percent / BiBr3 / acetonitrile; H2O / 8 h / 20 °C
4.1: 92 percent / TEMPO; NaClO2; NaClO / acetonitrile; aq. phosphate buffer / 18 h / 40 °C / pH 6.7
View Scheme
参考文献
Jiang, Sheng; Li, Peng; Lai, Christopher C.; Kelley, James A.; Roller, Peter P.
Journal of Organic Chemistry, 2006 , vol. 71, # 19 p. 7307 - 7314
反应条件
1: 92 percent / BiBr3 / acetonitrile; H2O / 8 h / 20 °C
2: 92 percent / TEMPO; NaClO2; NaClO / acetonitrile; aq. phosphate buffer / 18 h / 40 °C / pH 6.7
View Scheme
参考文献
Jiang, Sheng; Li, Peng; Lai, Christopher C.; Kelley, James A.; Roller, Peter P.
Journal of Organic Chemistry, 2006 , vol. 71, # 19 p. 7307 - 7314
反应条件
1: 90 percent / Na / tetrahydrofuran / Ambient temperature
2: aq. KOH / methanol / 2 h / Ambient temperature
View Scheme
参考文献
Somlai, Csaba; Penke, Botond; Peter, Antal
Journal fur Praktische Chemie - Chemiker - Zeitung, 1997 , vol. 339, # 5 p. 464 - 466
反应条件
1: 90 percent / Na / tetrahydrofuran / Ambient temperature
2: aq. KOH / methanol / 2 h / Ambient temperature
View Scheme
参考文献
Somlai, Csaba; Penke, Botond; Peter, Antal
Journal fur Praktische Chemie - Chemiker - Zeitung, 1997 , vol. 339, # 5 p. 464 - 466
反应条件
potassium hydroxide in methanol
2 h; Ambient temperature;
参考文献
Somlai, Csaba; Penke, Botond; Peter, Antal
Journal fur Praktische Chemie - Chemiker - Zeitung, 1997 , vol. 339, # 5 p. 464 - 466
参考文献
Maerki; Oppliger; Thanei; Schwyzer
Helvetica chimica acta, 1977 , vol. 60, # 3 p. 798 - 806
反应条件
1: (catalytic hydrogenation)
2: aq. CF3CO2H
View Scheme
参考文献
Maerki; Oppliger; Thanei; Schwyzer
Helvetica chimica acta, 1977 , vol. 60, # 3 p. 798 - 806
